Title: Adverse Effects of Combined Lipid Emulsion + VA-ECMO in Poisoned Patients
題目：中毒患者聯合應用脂肪乳劑和動靜脈體外膜肺氧合（VA-ECMO）的不良反應
Author: Bryan Hayes
作者：Bryan Hayes
翻譯：江利冰 校對：肖鋒

A new review summarized published adverse effects when IV lipid emulsion is used along with venous-arterial extracorporeal membrane oxygenation (VA-ECMO) in patients with cardiotoxic drug poisoning.
Not surprisingly, running fat through the ECMO circuit can cause some issues. Here's what's been published:
一項最新的綜述總結了當具有心臟毒性劑中毒時，聯合使用靜脈注射脂肪乳劑和動靜脈體外膜肺氧合的不良反應。果然，在體外膜肺環路中輸送脂肪會引起一些問題。以下是發表的內容：
• cracking of stopcocks
• 活塞的破裂
• fat emulsion agglutination
• 脂肪乳劑的凝集
• clogging and associated malfunction of the membrane oxygenator
• 堵塞以及相關的膜氧合器的功能障礙
• increased blood clot formation in the circuit
• 環路中血栓形成增加

It's unclear how these findings should change management if using both treatment modalities, but at the very least, be aware that fat depostion in the VA-ECMO circuits and increased blood clot formation can occur.
目前還不清楚這些發現會怎么改變同時使用這兩種治療方法時的處理策略，但是至少應該意識到當脂肪乳在動靜脈體外膜肺環路中輸送時，血栓的形成會增加。
References
參考文獻
Lee HM, et al. What are the adverse effects associated with the combined use of intravenous lipid emulsion and extracorporeal membrane oxygenation in the poisoned patient? Clin Toxicol. 2015 Jan 29. [Epub ahead of print, PMID 25634667]
http://www.ncbi.nlm.nih.gov/pubmed/25634667