Title: Dexmedetomidine for Cocaine Induced Sympathomimetic Activity?
題目：右美托咪定治療可代因導致的擬交感神經活性
Author 作者: Fermin Barrueto

Cocaine toxicity is characterized by the sympathomimetic toxidrome: tachycardia, hypertension, hyperpyrexia, diaphoresis as well as sodium channel blocking effects that can cause local anesthesia topically, QRS widening and even seizure.
可代因中毒的特點是擬交感神經中毒癥狀：心動過速，高血壓，高熱，大汗，和由鈉離子通道阻斷作用產生的局部麻醉作用，QRS增寬，和癲癇。
Usual treatment for a cocaine toxic patient is benzodiazepines and cooling. Be wary of end organ damage, trauma and seizures.
對于一個可代因中毒病人的常規治療包括苯二氮卓類藥物和降溫。要警惕臟器衰竭，外傷和癲癇。
There was a recent study that looked at dexmedetomidine to treat the sympathomimetic effects. Placebo-controlled trial used cocaine-addicted volunteer and applied intranasal cocaine. Measuring skin sympathetic nerve activity and skin vascular resistance.
最近發表的一個文獻研究了用右美托咪定治療（可代因導致的）擬交感神經反應。這個安慰劑對照試驗給可代因成癮自愿者用鼻內噴化可代因，測量皮膚交感神經活性和皮膚血管阻力。
This highlights the incredible physiologic mechanism of catecholamine release from the CNS with cocaine.
試驗結果進一步證實了可代因產生的中樞神經系統兒茶酚胺釋放的生理機制。
References 參考文獻：
Dexmedetomidine as a novel countermeasure for cocaine-induced central sympathoexcitation in cocaine-addicted humans.
Kontak AC, Victor RG, Vongpatanasin W. Hypertension. 2013 Feb;61(2):388-394